Prostate Cancer
Conditions
Keywords
Genetic Risk Perception and Beliefs, Biospecimen Donation for Genetic Risk Testing
Brief summary
The exploring men's prostate cancer genetic risk perceptions and willingness to give a biospecimen for genetic risk testing study aims to assess prostate cancer genetic risk and susceptibility beliefs among unaffected men of diverse races/ethnicities who are considering undergoing prostate cancer screening and their willingness of men to provide a biospecimen (saliva sample) and test the samples for prostate cancer aggressiveness and determine risk category based on SNP genetic profile.
Interventions
OTHERQuestionnaire
Participants will be asked to complete a questionnaire on demographics, risk beliefs and perception and prostate cancer screening behaviors, intentions and awareness of informed decision making.
OTHERSaliva Sample
Participants will be asked to provide a saliva sample for genetic risk testing to generate a SNP risk profile using a saliva sample collection kit with collection, storage and mailing instructions. We will assess the proportion of consented men who will provide a saliva sample.
Sponsors
H. Lee Moffitt Cancer Center and Research Institute
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Racially/ethnically diverse men with emphasis on Men of African Ancestry. * Age 40 and older . * No personal prostate cancer history/diagnosis. * With or without family history of prostate cancer.
Exclusion criteria
* Previous personal Prostate Cancer history/diagnosis * Under 40 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prostate Cancer Genetic Risk and Susceptibility Beliefs | Up to 6 Months | Prostate Cancer Genetic Risk and Susceptibility beliefs will be summarized based on single items on the Prostate Cancer Risk Perception Questionnaire. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Polygenic Risk Score (PRS) of Saliva Samples | Up to 6 Months | Polygenic Risk Score (PRS) of Saliva Samples will be based on genetic profiles from Single Nucleotide Polymorphisms (SNPs). Identified as prostate cancer susceptibility loci, genetic risk of developing prostate cancer will be categorized into 5 groups: Very Low Risk (\< 10%), Low Risk (10-25%) Moderate Risk (25-75%), High Risk (75-90%) or Very High Risk (\>90%). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJong Park, PhD
Moffitt Cancer Center
Outcome results
None listed