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Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor

Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06764667
Enrollment
60
Registered
2025-01-08
Start date
2025-02-10
Completion date
2026-01-31
Last updated
2025-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Donor Nephrectomy, Perioperative Pain Management

Keywords

Quadratus lumborum block, Spinal anesthesia adjuvant, Laparoscopic donor nephrectomy, Perioperative pain management

Brief summary

This study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.

Interventions

PROCEDURESpinal anesthesia adjuvant

Patients in this arm will receive 10 mg 0.5% hyperbaric Bupivacaine, 100 mcg Morphine, 100 mcg Sulfas Atropine, and 0.9% normal saline to total volume of 4 ml before induction of anesthesia.

Patients in this arm will receive quadratus lumborum block with 20-30 ml of 0.25% Bupivacaine after induction of anesthesia and after operation.

PROCEDUREGeneral Anesthesia

The subject will undergo preoxygenation with 100% oxygen for 3 minutes. Following preoxygenation, anesthesia induction will be performed using lidocaine at a dose of 1.5 mg/kg, fentanyl at 1.5 mcg/kg, and propofol at 2.0 mg/kg. Once the subject is adequately sedated, baseline neuromuscular monitoring using the train-of-four (TOF) technique will be conducted, followed by the administration of rocuronium at a dose of 0.8 mg/kg. Endotracheal intubation will be performed using direct laryngoscopy once the TOF value reaches 0, utilizing an appropriately sized endotracheal tube (ETT). Ten milligrams of intravenous dexamethasone is administered after induction.

Sponsors

Dr Cipto Mangunkusumo General Hospital
CollaboratorOTHER
Indonesia University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Patients aged 18-65 years undergoing laparoscopic donor nephrectomy * Patients with BMI ≤ 35 kg/m2 * Patients with American Society of Anesthesiology (ASA) physical status 1-2 * Patients who are willing to participate in this study

Exclusion criteria

* Cardiovascular disease (uncontrolled stage 2 hypertension, heart failure, arrhytmia) * Recent onset cerebrovascular diseasae of \< 3 months * Infection on spinal site * Coagulopathy * Elevated intracranial pressure * Severe renal or liver dysfunction * Valvular heart disease or atrioventricular block

Design outcomes

Primary

MeasureTime frameDescription
Postoperative painHour 2, 6, 12, and 24Postoperative pain measured with Numerical Rating Scale (NRS) during rest and movement.
Opioid requirementHour 2, 6, 12, and 24Morphine requirement on Patient-Controlled Analgesia (PCA).

Countries

Indonesia

Contacts

Primary ContactDita Aditianingsih, Prof.
ditaaditiaa@gmail.com+628151819244

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026