Molecular and Microbiota Signatures Underlying Colonic Diverticular Disease

Molecular and Microbiota Signatures Underlying Colonic Diverticular Disease - Caratterizzazione Dei Meccanismi Molecolari e Del Microbiota Nella Malattia Diverticolare Del Colon

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06764550

Acronym

GR-Barbaro

Enrollment

150

Registered

2025-01-08

Start date

2020-03-05

Completion date

2025-03-31

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diverticular Disease of Colon

Brief summary

The pathogenesis of diverticular disease is likely multifactorial in origin. This project aims to study the involvement of environmental factors in the pathophysiology of diverticular disease, the underlying molecular mechanisms, and alterations in the microbiota.

Detailed description

The pathogenesis of diverticular disease is likely multifactorial in origin. Some studies have demonstrated the role of genetic factors, while others have highlighted the role of environmental factors. The present project aims to study the involvement of environmental factors in the pathophysiology of diverticular disease, the underlying molecular mechanisms, and alterations in the microbiota.

Interventions

OTHERThis is an observational study, participants are not assigned an intervention as part of the study.

This is an observational study, participants are not assigned an intervention as part of the study.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Age between 18 and 75 years. * Belonging to one of the following groups: 1. Patients with diverticula of the colon without symptoms. 2. Patients symptomatic for diverticular disease. 3. Subjects undergoing colonoscopy for colorectal cancer prevention or follow-up of previous polypectomies, asymptomatic for digestive symptoms. * Obtaining informed consent.

Exclusion criteria

* Acute complicated diverticulitis (bleeding, perforation) * Previous colon surgery * Antibiotics or laxatives within the past 90 days * Pregnancy and/or lactation * Systemic and psychiatric disorders * Asthma, food allergies and other allergic-type disorders * Possible diseases leading to intestinal bacterial contamination (diabetes, blind loop syndrome, rheumatologic diseases).

Design outcomes

Primary

Measure	Time frame	Description
Assess the interaction between host factors and gut microbiota	3 years	Assess the interaction between host factors and gut microbiota

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026