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Neural Changes in Stroke Patients During Challenging Walking Tasks.

Neural Mechanism Changes in Stroke Patients During Challenging Environments

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06764290
Enrollment
60
Registered
2025-01-08
Start date
2024-04-01
Completion date
2025-02-28
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Electroencephalography, gait rehablitation, challenging task

Brief summary

For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered. Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds.

Detailed description

Stroke participants will wear a 32-lead electroencephalogram electrode cap (Zhentai Technology Company, Xi 'an, China), first walk on a flat ground for 60 seconds, rest for 2 minutes, then walk on the pedal for 60 seconds, rest again for 2 minutes, and walk for 60 seconds with eyes-covered.

Interventions

Pedal walking is a challenging walking task that can be used as a form of physical therapy for stroke participants.

OTHERvisual occlusion

Walking with eyes-covered is a challenging walking task that can be used as a form of physical therapy for stroke participants.

Sponsors

Nanjing Medical University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* First-time occurrence of stroke confirmed by computed tomography or magnetic resonance imagingClinical diagnosis of stroke * Disease duration of more than 14 days, less than 1 year * Able to walk independently but with a lingering abnormal gait

Exclusion criteria

* Lesions accumulate in the brainstem * Lesions accumulate in the cerebellum * Impaired vision * Severe cognitive impairment

Design outcomes

Primary

MeasureTime frameDescription
Weight Phase Lag IndexThe study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 secondsThe Weighted Phase Lag Index (WPLI) is a measure used to quantify phase synchronization in electrophysiological data.Continuously measure the connectivity of the coupling of neural oscillatory activity in the brain, while being statistically more powerful in detecting changes in signal phase synchronization.The WPLI ranges from 0 to 1, with 0 indicating no phase synchronization and 1 indicating complete phase synchronization.
Relative powerThe study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 secondsThe electroencephalogram signal in the time domain is converted into the relevant information in the frequency domain, the frequency bands are divided, and the relative power results of each channel in each frequency band are derived. Among them, delta:1-4Hz, theta:4-8Hz, alpha:8-15Hz, beta:15-30Hz, gamma:30-45Hz.

Countries

China

Contacts

Primary ContactJing Zhao, master
18817892579@163.com+8618817892579

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026