Frailty, Gastric (Stomach) Cancer, Malnutrition Elderly, Sarcopenia
Conditions
Keywords
gastric cancer, skeletal muscle mass, frailty, sarcopenia
Brief summary
The primary aim of this study was to quantify the diagnosis of pre-surgical skeletal muscle mass in elderly gastric cancer patients and to analyse its correlation with frailty. The second aim was to investigate whether skeletal muscle mass, or sarcopenia, is associated with mobility and nutritional status, and anxiety and depression. The main questions it aims to answer are whether skeletal muscle mass is significantly associated with frailty and whether it can be used as a brief screening tool for preoperative frailty.
Interventions
OTHERSkeletal muscle mass and frailty
Measurement correlation variable
Sponsors
Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed with gastric cancer by endoscopy or pathology; age \>60 years old; radical gastrectomy was proposed; be able to communicate simply in writing and verbal.
Exclusion criteria
* received preoperative radiotherapy or chemotherapy; combined with other sites of malignant tumors; combined with severe heart, liver, lung and renal insufficiency; recent using hormones, immunosuppressants; with physical disabilities.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle mass | Within 24 hours of admission | Skeletal muscle mass was measured by bioelectrical impedance analysis(BIA) and was classified as sarcopenia if it was less than 7.0 kg/m2 in men and 5.7 kg/m2 in women. |
| frailty | Within 24 hours of admission and discharge | The Tilburg frailty scale was used to assess the frailty of older people with gastric cancer. The Tilburg frailty scale was compiled by Gobbens et al. The scale contains 15 items in three dimensions of physical, psychological and social frailty. The total score of the scale is 0-15 points and the cut-off value of the total scale was 5, with higher score indicating more severe frailty. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nutritional Status | Within 24 hours of admission and discharge | The Mini Nutritional Assessment Short-form (MNA SF) scale was used to assess the nutritional status of older people with gastric cancer, which was a simplified version of the MNA scale developed by Rubenstein et al\[. The total score of this scale is 14, 12\ 14 points indicate normal nutrition, 8\ 11 points indicate the risk of nutrition, ≤7 points indicate malnutrition. |
| anxiety and depression | Within 24 hours of admission and discharge | Anxiety and Depression in older people with gastric cancer were assessed by the Chinese version of the Hospital Anxiety and Depression Scale (HADS), which was developed by Zigmond AS et al\[23\]. The scale has 14 items, 7 of which are used to assess depressed and 7 of which are used to assess anxiety. Each item has a score of 1-4 point and a total score of more than 7 indicates the presence of anxiety or depression. |
Countries
China
Outcome results
None listed