Hodgkin Lymphoma
Conditions
Brief summary
Pulmonary toxicity during Hodgkin lymphoma treatment is significant for a variety of reasons, ranging from clinical care to therapeutic innovation and patient outcomes.
Detailed description
Understanding chemotherapy-induced pulmonary issues, particularly bleomycin-induced toxicity, might enhance treatment efficacy, side effects, and quality of life for Hodgkin lymphoma patients. For Hodgkin lymphoma chemotherapy patients with pulmonary difficulties, which result in significant patient morbidity and mortality, early detection, proactive surveillance, and rapid management are required. Identifying the prevalence, risk factors, and clinical signs of pulmonary toxicity helps clinicians stratify treatment.
Interventions
DIAGNOSTIC_TESTgroup 1
To determine treatment-induced pulmonary toxicity prevalence and risk factors in Hodgkin lymphoma patients during chemotherapy or radiation therapy.
Sponsors
Superior University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients diagnosed with Hodgkin lymphoma (HL) receiving treatment. * Patients of all ages and both genders. * Patients with histologically confirmed HL, as per the WHO 2016 classification. * Patients who have undergone pulmonary function testing and assessment at specified time points during their treatment course. * Patients with complete medical records documenting treatment regimens, including chemotherapy and radiotherapy details.
Exclusion criteria
* Patients with a diagnosis of another malignancy. * Patients with incomplete medical records or missing data on treatment regimens and pulmonary function assessments. * Patients with a history of significant pulmonary comorbidities, such as chronic obstructive pulmonary disease (COPD), interstitial lung disease, or pulmonary fibrosis, before HL diagnosis. * Patients who are unable to complete pulmonary function tests.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| high-resolution computed tomography | 12 Months | An HRCT (high-resolution computed tomography) scan is a type of CT scan healthcare providers use to get detailed images of your lungs. Providers most commonly use it to diagnose and monitor interstitial lung diseases and conditions that affect your small airways and alveoli (air sacs). |
Countries
Pakistan
Outcome results
None listed