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Investigation of the Effect of I-PRF Application on Pain in Alveolitis

Investigation of the Effect of I-PRF Application on Pain in Alveolitis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06761001
Enrollment
60
Registered
2025-01-07
Start date
2024-10-20
Completion date
2025-02-18
Last updated
2025-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Osteitis, Pain, Dry Socket

Keywords

injectable platelet rich fibrine

Brief summary

Literature review showed that there are no studies on the use of i-PRF in alveolitis cases. The aim of this study was to investigate the effect of i-PRF on the treatment of alveolitis. The hypothesis of the study was that i-PRF applied to alveolitis patients would reduce pain.

Detailed description

The present study will include 60 healthy patients over 18 years of age with alveolitis. 60 patients will be randomly divided into two groups: Control and I-PRF. After irrigation of the sockets, no substance will be applied to the control group, and I-PRF will be applied to the study group. Postoperative pain will be measured on the 3rd and 7th days.

Interventions

DEVICEI-PRF

After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution. I-PRF is given to patients in the experimental group.

OTHERControl

After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution.

Sponsors

Eskisehir Osmangazi University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Healthy individuals without systemic disease Patients with complete data and attending their appointments

Exclusion criteria

Patients who smoke Pregnant or breastfeeding female patients with bleeding disorders and diabetics Patients currently or previously using bisphosphonates or receiving radiotherapy to the jaw Patients unable to consent to participate in the study

Design outcomes

Primary

MeasureTime frameDescription
Change in post-operative pain assessed: visual analog (VAS) scalepostoperative 3rd, and 7th daysVAS measured on a 10cm scale, where 0 represents no pain and 10 represents maximum pain

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 5, 2026