Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 3B, Chronic Kidney Disease Stage 5, Diabetes Mellitus, Fluorescein Angiography, Acute Kidney Injury
Conditions
Keywords
Fluorescein Angiography, Acute kidney injury, Chronic kidney disease, Diabetes
Brief summary
Our study hypothesizes that fluorescein exposure in diabetic patients with advanced chronic kidney disease results in deterioration of kidney function. It will therefore aim to evaluate the incidence of acute kidney injury induced by fluorescein in diabetic patients with CKD. The objective is to determine the incidence, severity and risk factors associated with this deterioration to improve the care of this specific population.
Detailed description
This study will assess the change in serum creatinine in patients with diabetes and advanced chronic kidney disease, after a fluorescein angiography. This is a before and after study that will include 35 patients from the department of ophtalmology over 6 months with a total follow-up for 3 months.
Interventions
DIAGNOSTIC_TESTFluorescein angiography
Fluorescein angiography
Sponsors
Saint-Joseph University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>18 years old with type 2 or type 1 diabetes and chronic kidney disease stage 3b to 5 (eGFR\<45 mL/min/1.73 m2)
Exclusion criteria
* Patients who do not give their consent * Patients who are allergic to fluorescein * Patients who are on dialysis * Patients who had fever, vomiting, diarrhea or any dehydration 48 hours before the intervention * Patients who had a treatment modification one week before the intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum creatinine | At day 4 | Change in serum creatinine from baseline to day 4 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Long-term change in serum creatinine | 3 months | Change in serum creatinine from baseline to end of the third month |
Countries
Lebanon
Contacts
Primary ContactMabel AOUN, M.D., M.P.H.
Backup ContactAnthony NOHRA, Medical Student
Outcome results
None listed