Role of Low Carbohydrate Nutrient in Healing of Infected Diabetic Foot

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06759688

Acronym

LCN

Enrollment

120

Registered

2025-01-06

Start date

2019-01-01

Completion date

2023-12-30

Last updated

2025-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carbohydrate Ingestion

Keywords

Diabetic foot wound infections,, Diabetic foot ulcer,, low carbohydrate dietary approaches.

Brief summary

A low-carbohydrate diet, when combined with standard wound care and diabetes management, appears to accelerate the healing of infected diabetic foot, improve blood glucose control, reduce systemic inflammation and promoting overall patient recovery. This approach could be considered a beneficial adjunct therapy in the treatment of diabetic foot infections.

Detailed description

The research was a case control study. It conducted prospectively from January 2019 to December 2023 in the surgery department of Aswan university hospital. It involving patients with diabetic foot infections. The patients were divided into two groups of patients. The first group committed to not eating carbohydrates in food. The second group ate their daily routine and did not adhere to the carbohydrate's restriction. The diabetic food infection classified from mild, moderate and sever, as per the Infectious Diseases Society of America (IDSA) Infection Severity Classification.

Interventions

BEHAVIORALCarbohydrates restriction

Patients followed a low carbohydrate dietary approach (LCDs). It means lower than 130 grams carbohydrates per day with special restriction restrictions on: * Artificial sugars (e.g., sweets, baked goods, pasta, bread). * Also, rice, butter made from vegetable oils and all types of oils except olive oil. They were allowed: * All types of fresh fruits and vegetable. * Boiled potatoes.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

Patients complained of diabetic foot infections graded 0 to 4 with absent signs of ischemia.

Exclusion criteria

Patients with foot gangrene grade 5 The presence of foot ischemia Those who refused to participate

Design outcomes

Primary

Measure	Time frame	Description
Change in the wound size and healing	3-6 months	Wound healing rate (%) = \[ (Initial wound size - Wound size after 1 week) / (Initial wound size)\] × 100

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026