Obesity and Obesity-related Medical Conditions
Conditions
Brief summary
It is known that more or less pronounced impairment of pulmonary function occurs after anesthesia. It has been demonstrated in the postoperative period in both patients undergoing general and regional anesthesia, in patients after intra-abdominal and superficial procedures, in overweight and normal-weight patients. It has also been shown that when general anesthesia is performed with the inhalation anesthetic sevoflurane, there is a slightly smaller reduction in lung function parameters than when only intravenous anesthetics are used. The purpose of this study is to evaluate lung function before induction and after awakening from general anesthesia depending on the inhalational anesthetic used in obese patients undergoing bariatric surgery
Interventions
DRUGDifferent drug type for conduction of general anesthesia
Patients will be randomly divided into two groups: patients for whom general anesthesia will be performed with sevoflurane and patients for whom general anesthesia will be performed with desflurane.
Sponsors
Medical University of Gdansk
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Obese patients qualified for bariatric surgery.
Exclusion criteria
* Patients who have absolute contraindications to spirometry testing, i.e: * with aneurysms of the aorta or cerebral arteries threatening to rupture, after recent vascular surgery * with increased intracranial pressure, after recent intracranial bleeding or head surgery within the cranial cavity * after acute conditions within 6 months prior to surgery such as stroke, myocardial infarction, unstable angina, pneumothorax * with uncontrolled hypertension * after recent eye surgery or a history of retinal detachment * with hemoptysis of unknown etiology. And patients unable to perform spirometry testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory input impedance (Zrs) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | Zrs will be measured with impulsed oscillometry |
| Resistive component (Rrs) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | Rrs will be measured with impulsed oscillometry |
| Reactive component (Xrs) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | Xrs will be measured with impulsed oscillometry |
| Resonant frequency (Fres) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | Fres will be measured with impulsed oscillometry |
| Area of reactance (Ax) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | Ax will be measured with impulsed oscillometry |
| Heart rate (HR) | Continuously during whole duration of anesthesia | HR will be measured by ecg in beat per minute |
| Pulse oximetry (SpO2) | Continuously during whole duration of anesthesia | SpO2 will be measured by light spectrometry percutaneous sensor in % |
| End tidal CO2 (etCO2) | Continuously during whole duration of anesthesia | etCO2 will be measured by capnography with infrared radiation sensor in mmHg. Sensor will be attached to breathing circuit. |
| Minimum alveolar concentration (MAC) | Continuously during whole duration of anesthesia | MAC will be measured based on exhaled anesthetic gas concentration in absolute numbers |
| Bispectral index (BIS) | Continuously during whole duration of anesthesia | BIS will be measured with Covidien BIS monitoring system in absolute numbers |
| Train of for (TOF) | Every 2.5 minutes during whole duration of anesthesia | TOF will be measured in absolute numbers |
| Non invasive blood pressure (NIBP) | Every 5 minutes during whole duration of anesthesia | NIBP will be measured with oscillometric method in mmHG |
| Forced vital capacity (FVC) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | FVC will be measured with spirometry |
| Volume that has been exhaled at the end of the first second of forced expiration (FEV1) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | FEV1 will be measured with spirometry |
| Mid-expiratory flow; the rates at 25% FVC (MEF25) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | MEF25 will be measured with spirometry |
| Mid-expiratory flow; the rates at 25% FVC (MEF50) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | MEF50 will be measured with spirometry |
| Peak expiratory flow (PEF) | 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia | PEF will be measured with spirometry |
Countries
Poland
Contacts
Primary ContactKarolina Obara, MD
Outcome results
None listed