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Analysis of Biological Progression and Regression of HELLP Syndrome in Time

Biological Evolution of HELLP Syndrome

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06758960
Enrollment
72
Registered
2025-01-06
Start date
2023-07-01
Completion date
2025-08-31
Last updated
2026-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HELLP Syndrome, Preeclampsia

Keywords

Preeclampsia, HELLP syndrome, Thrombocytopenia, Maternal mortality

Brief summary

Prospective observational study about progression and regression of biological parameters of HELLP syndrome

Detailed description

Data collection included a comprehensive review of pathological histories, identification of complications based on clinical presentation, daily monitoring of biological parameters, documentation of transfusion events, recording of corticosteroid administration according to gestational age, and detailed reporting of extraction and analgesia techniques.

Interventions

None listed

Sponsors

CHU Mohammed VI Marrakech
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
No

Inclusion criteria

* Pregnant women who are admitted to the maternal ICU for a biological HELLP syndrome

Exclusion criteria

* Patients whose biological presentation was attributable to other conditions, such as microangiopathies or leukemia. * Patients who benefited from plasma exchange therapy

Design outcomes

Primary

MeasureTime frameDescription
Platelets countUp to 10 daysPlatelets count will be monitored daily before and after delivery

Secondary

MeasureTime frameDescription
Concentration of Lactate dehydrogenaseUp to 10 daysMonitored daily before and after delivery
Concentration of Liver enzymesUp to 10 daysdaily monitoring of alkaline phosphatase, alanine transaminase before and after delivery

Countries

Morocco

Contacts

STUDY_DIRECTORMeryem Essafti, Assistant Professor

CHU Mohammed VI Marrakech

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 1, 2026