Cardiac Magnetic Resonance Predictors of Outcome of Rhythm Control in Patients with Atrial Fibrillation/Flutter

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06758895

Enrollment

Registered

2025-01-06

Start date

2025-01-31

Completion date

2026-05-31

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhythm Monitoring

Keywords

CMR predictors of rhythm control in patient with AFibirilation/flutter

Brief summary

evaluate the impact of various features in CMR on the mid-term/long-term success rate of rhythm control for paroxysmal atrial fibrillation/flutter .

Detailed description

* Atrial fibrillation/flutter are widely prevalent. * Reported antiarrhythmic drug efficacy to restore & maintain sinus rhythm is 52% which is far from optimal. * On the other hand, 5-year arrhythmia-free survival after catheter ablation was previously reported to be 63%. * Therefore, there is a need for better characterization of the underlying atrial substrate, to improve treatment outcomes in terms of efficacy and safety

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age\>18 years. * Patients undergoing successful cardioversion (pharmacologic or electric) for atrial fibrillation/flutter, OR symptomatic patients with paroxysmal atrial fibrillation/flutter scheduled for trans-catheter ablation. * Index cardioversion OR Index ablation procedure.

Exclusion criteria

* LA thrombus on TEE or CMR. * Contraindications to CMR. * Contraindications to Gd-based contrast.

Design outcomes

Primary

Measure	Time frame	Description
Recurence in patient with AF or flutter after pharmacological or interventional rythm control	Baseline	* Non-invasive rhythm control arm: Predictors of atrial fibrillation recurrence within 6 months of cardioversion or the need for ≥2 cardioversions in the 1st year after initial cardioversion. * Ablation arm: Predictors of success rate (acute and mid term) of ablation on multivariable logistic regression analysis.

Secondary

Measure	Time frame	Description
parameters for safe ablation	Baseline	* Ablation arm: Predictors of esophageal thermal injury (ETI). * Arterial embolic events in both arms.

Countries

Egypt

Contacts

Primary ContactMaryem Ashraf Abd El-Naeem Sayed, Resident Doctor

reemy.rooma77@gmail.com+2001097400995

Backup ContactAmr EL-Badry Ibrahim, Lecture of cardiology

aelbadry@aun.edu.eg+2001060701601

Outcome results