Gestational Diabetes Mellitus (GDM), Hyperemesis Gravidarum - Severe, Resistin
Conditions
Keywords
First trimester, maternal serum resistin, hyperemesis gravidarum, HG, GDM
Brief summary
This cross-sectional case-control study was conducted in Tuzla State Hospital Obstetrics Clinic in Turkey. The study evaluated 400 pregnant women during their first trimester of pregnancy. Many pregnant women (50-90%) experience nausea and vomiting during their first trimester; however, some patients have a disease called hyperemesis gravidarum (HG) characterized by very severe nausea and vomiting that may require hospitalization. resistin is a peptide which is secreted primarily by human adipocytes and mononuclear cells. Evidence suggests that resistin increases plasma glucose concentration, reduces glucose intake by adipocytes, and promotes insulin resistance. Considering the HG effect on endocrinologic and metabolic complications, we hypothesized that resistin levels in maternal serum may change in the presence of HG; therefore, the aim of the present study was to evaluate these resistin levels during the first trimester and their correlation with HG severity.
Interventions
DIAGNOSTIC_TESTResistin
Considering the HG effect on endocrinologic and metabolic complications, resistin levels in maternal serum may change in the presence of HG severity
Sponsors
Dr. Lutfi Kirdar Kartal Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Those who applied in the first trimester and had a mid-trimester OGTT result
Exclusion criteria
1\) multifetal pregnancy, 2) fetal chromosomal or structural anomalies, 3) pregestational DM, 4) chronic hypertension or history of preeclampsia, 5) thyroid disease, 5) chronic kidney disease, 6) autoimmune disease, or 7) long-term use of aspirin or glucocorticoids 8) without OGTT results.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PUQE | Immediately after admission in the first trimester | the PUQE-24 questionnaire was used to evaluate the severity of HG, and those with a score of ≤6 were considered as mild HG, 6-12 as moderate HG, and ≥13 as severe HG |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resistin levels | Immediately after admission in the first trimester | Resistin levels rise with HG severity |
| OGTT | admission in 24-28 th week in pregnancy | After 75 grams of solution was given, blood glucose values were evaluated again at 1st and 2nd hours. GDM was diagnosed when one of the 3 levels of blood sugar was reached or exceeded (Fasting: 92 mg/dl, 1 hour later: 180 mg/dl, 2 hours later: 153 mg/dl). |
Countries
Turkey (Türkiye)
Outcome results
None listed