Low-Level Laser Therapy and Injectable Platelet-Rich Fibrin for Thin Gingival Phenotype.

Evaluation of Low-Level Laser Therapy as Adjunctive to the Injectable Platelet-Rich Fibrin in the Management of Patients With Thin Gingival Phenotype.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06756854

Enrollment

Registered

2025-01-03

Start date

2023-09-12

Completion date

2024-06-15

Last updated

2025-01-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Diseases

Keywords

I-PRF, thin gingival phenotype low level laser

Brief summary

Management of thin gingival phenotype using non-surgical methods (injection of liquid platelet rich fibrin and exposure to low level laser therapy

Detailed description

Thin gingival phenotype can lead to recession and root exposure. Liquid prf can be obtained by centrifugion of blood sample on speed 700 rpm for 3 min, then injection of this liquid in the attached gingiva and muco-gingival junction (3 times with 7 days interval) for the first group. The second group will be injected with I-PRF in the same method in addition to exposure to Low Level Laser therapy (after each injection of I-PRF). This method is expected to increase the thickness of the gingiva.

Interventions

BIOLOGICALBiologic Agent: injectable platelet rich fibrin.

injection of I-PRF to thin gingival phenotype 3 times with 7 days interval between sessions.

OTHERinjecable platelet rich fibrin, and low level laser therapy radiation.

injection of I-PRF+ exposure to LLLT to thin gingival phenotype 3 times with 7 days interval between sessions.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Masking description

I-PRF biologic product

Intervention model description

group1: received I-PRF alone, and group 2: received I-PRF+LLLT

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* free systimatically good oral hygiene gingival thickness less than 1mm

Exclusion criteria

* pregnancy or lactation pereiodontitis periodontal surgery orthodontic ttt tooth mobility,bruxism,crowding,missing or supernumerary teeth smoking

Design outcomes

Primary

Measure	Time frame	Description
Gingival thickness improvement in millimeters.	6 months after treatment	clinical parameter
Keratinized tissue width improvement in millimeters.	6 months after treatment	Clinincal parameter.

Secondary

Measure	Time frame	Description
Improvement of gingival index.	6 months after treatment	Clinical parameter.
Improvement of bleeding on probing.	6 months after treatment	Clinical parameter.
Improvement of sulcus depth.	6 months after treatment	Clinical parameter.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026