Chronic Obstructive Pulmonary Disease
Conditions
Keywords
Blood flow restriction training, Chronic Obstructive Pulmonary Disease
Brief summary
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in COPD patients.
Detailed description
The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. These comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. Addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of COPD. According to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. Blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to COPD rehabilitation. The research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with COPD. The findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of COPD.
Interventions
BEHAVIORALAerobic exercise intervention
The aerobic exercise intervention will utilize an ergometer. The program will be conducted 2-3 times per week over a 3-month period.
BEHAVIORALDisease and exercise suggestion
The participants will be provided by educational program about COPD self-care and home-based exercise approach.
BEHAVIORALBlood flow restriction (BFR) intervention
Blood flow restriction (BFR) intervention will combine aerobic exercise on the ergometer with BFR training. The program will be conducted 2-3 times per week over a 3-month period.
Sponsors
National Cheng Kung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. COPD classified as levels 2-4. 2. Stable condition without worsening in the past three months. 3. No participation in any rehabilitation program within the past six months. 4. Ability to understand and follow verbal commands and cooperate with an exercise training program.
Exclusion criteria
1. Unconscious or unable to cooperate with the evaluator. 2. Hospitalization due to acute illness within the past three months. 3. Severe joint diseases or history of lower limb surgery. 4. Severe cardiovascular disease (e.g., presence of a cardiac pacemaker or acute myocardial infarction within the past six months). 5. Dependence on oxygen supply.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygen consumption (VO2) | Change from baseline (0 week) to follow up (20 weeks) | Oxygen consumption examined by cardiopulmonary exercise test |
| Diaphragm capacity | Change from baseline (0 week) to follow up (20 weeks) | Diaphragm capacity examined by diaphragmatic ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary function test | Change from baseline (0 week) to follow up (20 weeks) | Pulmonary function test examined by spirometer. Spirometry is a physiological test that measures the ability to inhale and exhale air over time. The main spirometry results are forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the FEV1/FVC ratio. |
| Maximum respiratory pressure | Change from baseline (0 week) to follow up (20 weeks) | Maximum respiratory pressure examined by pressure meter |
| Functional capacity | Change from baseline (0 week) to follow up (20 weeks) | Functional capacity examined by 6MWT |
| Quality of life score (COPD-related questionnaire-II) | Change from baseline (0 week) to follow up (20 weeks) | COPD Assessment Test (CAT) questionaire |
| Quality of life score (COPD-related questionnaire-III) | Change from baseline (0 week) to follow up (20 weeks) | St George's Respiratory Questionnaire (SGRQ) |
| Quality of life score (COPD-related questionnaire-I) | Change from baseline (0 week) to follow up (20 weeks) | Quality of life score examined by mMRC Questionnaire. |
| Heart Rate Variability | Change from baseline (0 week) to follow up (20 weeks) | Heart Rate Variability examined by autonomic nervous system |
Countries
Taiwan
Contacts
Primary ContactKun-Ling Tsai, Ph.D.
Backup ContactYu-Ting Huang, M.S.
Outcome results
None listed