Diagnostic Techniques, Ophthalmological, Liver Cirrhoses, Liver Transplantation
Conditions
Keywords
Diagnostic Techniques, Ophthalmological, liver transplantation, Liver Cirrhoses
Brief summary
This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics. Explore whether it is possible to construct a clinical prediction model for liver transplantation by incorporating ocular biometric features, in order to optimize disease management before and after liver transplantation.
Detailed description
This study is a bidirectional cohort study, which retrospectively analysed data from a prospective database to construct a model, and prospectively collected patient information from preoperative to postoperative for model improvement and validation.
Interventions
DIAGNOSTIC_TESTOphthalmic examination
Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.
DIAGNOSTIC_TESTGeneral Condition Examination
Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.
Sponsors
First Affiliated Hospital, Sun Yat-Sen University
Second Affiliated Hospital, Sun Yat-Sen University
Guangdong Provincial People's Hospital
Nanfang Hospital of Southern Medical University, Guangdong of China
Zhongshan People's Hospital, Guangdong, China
Guangdong Provincial People's Hospital, China
First People's Hospital of Foshan
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Age greater than or equal to 18 years old; 2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis; 3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results; 4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters; 5. Voluntarily follow the clinical trial protocol and sign the informed consent form.
Exclusion criteria
1. History of other organ transplant surgeries; 2. History of intraocular laser treatment, medication injection, and surgery; 3. History of high myopia, glaucoma, and retinal choroidal related eye diseases; 4. History of major systemic diseases other than liver disease; 5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The performance of predicting the prognosis of liver transplantation | 1 week and 1 year after liver transplantation | Based on the outcomes of early graft dysfunction and 1-year graft survival rate, the area under the receiver operating characteristic curve, specificity, and sensitivity of the model |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The performance of the model in assessing the severity of liver disease | 1 year | The confusion matrix of the model based on the MELD score results |
Countries
China
Contacts
Primary ContactZizheng Cao, M.D.
Outcome results
None listed