Fiberoptic Bronchoscopy
Conditions
Brief summary
To observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy diagnosis and treatment
Detailed description
Dexmedetorimidine nasal spray is a new dosage form, which is simple and easy to achieve sedative and anti-anxiety effects by nasal spray mucosa. In the dose range from 50 to 100 μ g, the sedation effect increased dose-dependent, with\> 2 μ g / kg administered, and the child could be successfully separated within 45min.Our study is to observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy diagnosis and treatment
Interventions
DRUGDexmedetomidine injection
Dexmedetomidine injection 3μg/kg
DRUGRemimazolam
remimazolam 0.5mg / kg
Sponsors
Tongji Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 6 Years
Healthy volunteers
No
Inclusion criteria
* Age 2-6 years old (24\~72 months); * ASA I-II; * sign the informed consent.
Exclusion criteria
* Severe rhinitis, nasal deformity; * abnormal liver and kidney function; * severe dehydration, severe malnutrition, hypoproteinemia or anaemia Hb \<10 g/dl; * children with neurological disease; * history of allergy to the study drug; * recent participation in other clinical studies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sedation success rate | 1day | MOSS / A score =4-point time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| recoving time | 1day | Wake up time |
| Drug dosage | 1day | dosage of dexmeditomidine and remimazolam |
Countries
China
Contacts
STUDY_CHAIRpu zhou, Dr.
Tongji Hospital
Outcome results
None listed