Asthma in Children
Conditions
Brief summary
Asthma affects around 260 million people globally, causing around 0.5 million deaths annually. Pediatric asthma remains a major global public health challenge, significantly affecting the quality of life for many children. Therefore, this study was planned to compare the effects of continuous versus intermittent nebulization of salbutamol in the treatment of acute severe asthma (ASA) in children visiting the emergency department of a tertiary childcare hospital in South Punjab, Pakistan.
Interventions
DRUGContinuous Nebulization of Salbutamol
Children received continuous nebulization of salbutamol at a concentration of 0.3 mg/kg/hour for 4 hours, with a minimum of 5 mg/hour and a maximum of 15 mg/hour administered via High Output Extended Aerosol Respiratory Therapy (HEART).
DRUGIntermittent Nebulization of Salbutamol
were treated with intermittent nebulization of salbutamol at a dose of 0.15 mg/kg/dose, administered through a face mask with an oxygen flow rate of 6-8 L per minute. They Children received at least 2-3 nebulizations and no more than 7.5 mg/dose every 30 minutes for 4 hours.
Sponsors
Nishtar Medical University
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Children of either gender * Aged 2 to 12 years * Diagnosed with moderate exacerbation of acute asthma according to British Guidelines on the Management of Asthma, with a clinical asthma score of 8 or more
Exclusion criteria
* Children who were prescribed with other first-line therapy, such as adrenaline or 3% NaCl nebulization * Presented at imminent risk of respiratory arrest * Congenital heart disease * Chronic respiratory disease * Neurological disorders * Children referred from any other hospital with no data available on emergency treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Discharge | 4 hours | When patients met the clinical criteria for discharge, which were an asthma score of 5 or less and a saturation level of over 94% on room air. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital stay | 24 hours | The length of stay in the hospital was calculated from admission to discharge. |
Countries
Pakistan
Outcome results
None listed