Efficacy of Antihistamine Drugs as Medical Expulsive Therapy Alone or in Combination With Alpha Blockers: A Prospective Randomized Controlled Study

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06754410

Enrollment

480

Registered

2024-12-31

Start date

2021-03-01

Completion date

2024-03-01

Last updated

2024-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower Ureteric Stones

Keywords

stones , ureter, tamsulosin

Brief summary

we investigate the Efficacy of Antihistamine Drugs as Medical Expulsive Therapy Alone or in Combination with Alpha Blockers in distal ureter stone

Interventions

DRUGTamsulosin

group A take tamsulosin once daily

DRUGCetirizine

give cetirizine once dailly

COMBINATION_PRODUCTCetirizine + Tamsulosin

both once daily

OTHERPlacebo

once dailly

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* all adult patients with lower ureter stone less than 10 mm

Exclusion criteria

* pregnant, solitary kidney, sensitivity to drugs

Design outcomes

Primary

Measure	Time frame
ureter stone free rate	4 weeks

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026