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Oral Health and Endometriosis: A Cohort Study

Oral Health Perception Among 4,079 Women With Endometriosis: A Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06753162
Acronym
Oral-Endomet
Enrollment
4079
Registered
2024-12-31
Start date
2023-01-01
Completion date
2024-12-01
Last updated
2025-01-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis

Keywords

endometriosis, Oral Health, Periodontitis, Gengivitis

Brief summary

A survey has been conducted thanks to a questionnaire composed of 45 questions. The study group was composed of 4079 women affected by endometriosis, recruited from dedicated communities present on the social network Facebook. The questionnaire investigated about: the endometriosis status, the kind of therapy, the presence of any sign and symptoms in the oral cavity, the presence of periodontal problems, the self-perception of the oral health status, the presence of other autoimmune diseases and oral hygiene and the eating habits, physical activity practiced, the life quality.

Detailed description

The questions were structured thanks to the collaboration of expert health professionals: gynecologist, dentist, dental hygienist, physiotherapist, dietician, psychologist to obtain targeted information on endometriosis, on the type of therapy, on any signs and symptoms in the oral cavity (perception health status, presence of periodontal problems), to investigate oral hygiene and dietary habits, physical activity, quality of life, the presence of other immune-based diseases. In the final part of the questionnaire there was a section in which women were free to tell their stories.

Interventions

None listed

Sponsors

University of Bari Aldo Moro
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
Yes

Inclusion criteria

* The only inclusion criterion was being at least 18 years old

Exclusion criteria

* • Pregnancy. * Administration of antibiotics in the last 15 days prior to entry into the study or indications for antibiotic prophylaxis. * Orthodontic Appliances. * Immunological diseases or use of drugs that can affect oral tissues (phenytoin, cyclosporine), nifedipine, chronic use of nonsteroidal anti-inflammatory drugs. * Refusal to participate in the study.

Design outcomes

Primary

MeasureTime frameDescription
Response Patterns Based on Multiple Correspondence Analysis Dimensions1 yearTo evaluate the possible correlations between endometriosis and the perception of periodontal disease, a score was created to summarize on a numerical scale the responses to survey questions describing the perception of oral cavity disorders. Multiple Correspondence Analysis (MCA) was used to explore relationships between responses. For the MCA, only questions with a p-value \< 0.25 in the univariate analysis were included. The responses to the questions were labeled as yes, no, and I don't know. In the case of question Q11, a grade was assigned to the responses as follows: Idk (I don't know), Grd0 (Insufficient), Grd1 (Average), Grd2 (Good), Grd3 (Very Good), and Grd4 (Perfect).
Epidemiological Analysis1 yearIt was statistically evaluated whether the severity of endometriosis increased significantly with age.
Comparative Analysis of Oral Cavity Disorders Across Different Stages of Endometriosis1 yearThe correlation between general gum bleeding and the stage of the disease was statistically evaluated.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026