Orthodontics
Conditions
Keywords
oral dysbiosis, orthodontics, oral microbiotis
Brief summary
Oral dysbiosis systematically develops during orthodontic treatment \[35\]\[36\]. Orthodontic appliances interfere with oral hygiene procedures and cause biofilm to accumulate, creating new retention zones, even in subjects who maintain correct oral hygiene \[37\]: * A group benefiting from intensive personalised prevention * A conventionally monitored group, with no personalised prevention. The hypothesis is that personalised prevention prevents dysbiosis from taking hold. If this hypothesis is confirmed, the concept could be extended to all patients, beyond orthodontics. Based on the biological signature (microbiological and immune), a risk profile of patients could be defined, making it possible to better personalise the prevention message, the method applied and the frequency of follow-up. The aim would be to rebalance dysbiosis through a personalised prevention approach tailored to the profile defined. It was decided to explore this hypothesis initially with orthodontic patients because they are captive, i.e. in the course of treatment requiring regular visits. Prevention is aimed first and foremost at healthy patients, with the aim of maintaining them in good health. The project focuses on young patients undergoing orthodontic treatment
Interventions
OTHERStandard Care Arm
standard care combined with personalised prevention
OTHERstandard care combined with personalised prevention
standard care combined with personalised prevention
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 20 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 12 to 20 (permanent dentition) requiring fixed orthodontic treatment.
Exclusion criteria
* Tobacco; * Overcrowded restorations, untreated caries, * lack of tooth mineralisation; * Medical pathologies; * Known immunodepression (congenital or acquired); * Taking a treatment that may induce general immunodepression; * Taking a probiotic; * Taking a concomitant treatment that may interact with oral health
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| viruses in biofilm | At inclusion | number of viruses measured in the biofilm |
| bacteria in biofilm | At inclusion | number of pathogenic bacteria measured in the biofilm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| plaque index | through study completion, an average of 1 year | scale QHI: quigley hein index |
| patient's satisfaction | at 12 months | Patient satisfaction on a numerical scale from 0 to 10. |
| toothbrush wear | through study completion, an average of 1 year | toothbrush wear with the Toothbrush Wear Index (TWI) |
| gingival index, | through study completion, an average of 1 year | gingival index mesured with Ginigical Index Loe&Silness scale |
| measurement of immune response | At inclusion | assay of salivary cytokines in ng/ml |
Countries
France
Contacts
Primary Contactlaurence LUPI, PUPH
Outcome results
None listed