Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06751654

Enrollment

1000

Registered

2024-12-30

Start date

2024-12-06

Completion date

2024-12-23

Last updated

2024-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS (Acute Respiratory Distress Syndrome), COPD (Chronic Obstructive Pulmonary Disease), Mechanical Power, Pneumonia, Weaning Failure

Keywords

Mechanical Power, COPD

Brief summary

A Comparison of Ventilator Parameters (TV, DP, Total Mechanical Power, etc.) Between Successfully and unsuccessfully Weaned Patients with COPD Undergoing Mechanical Ventilation Due to Respiratory Failure, and Diagnosed with Pneumonia or ARDS in the Intensive Care Unit.

Detailed description

The objective of this study is to investigate which mechanical ventilation parameters and clinical findings influence weaning success by comparing successful and unsuccessful weaning patient groups among patients diagnosed with COPD who were intubated and monitored for more than five days in the intensive care unit. The findings of this study may contribute to the development of future treatment protocols and criteria for evaluating the weaning process. This study is planned to be conducted in two centers: Bakırköy Dr. Sadi Konuk Training and Research Hospital in Istanbul and Shahid Beheshti University of Medical Sciences, Masih Daneshvari Hospital in Tehran. This multicenter study aims to facilitate the comparison of data obtained under different geographical and clinical conditions, thereby enabling a broader analysis of factors influencing the weaning process across a larger patient population.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 18 years and older * COPD-diagnosed patients who have been intubated and stayed in the ICU for more than 5 days

Exclusion criteria

* Patients without electronic medical records * Patients under 18 years of age * Patients diagnosed with pulmonary malignancy * Patients who stayed in the ICU for less than 5 days * Patients monitored in the ICU without intubation

Design outcomes

Primary

Measure	Time frame	Description
Successful Weaning	48 hours	The primary outcome of this study will be the successful weaning from mechanical ventilation. This will be defined as the patient being successfully extubated and maintaining adequate oxygenation for more than 48 hours without requiring reintubation or mechanical ventilation support.

Secondary

Measure	Time frame	Description
Mechanical Ventilator Parameters	48 hours	A comparison of total mechanical power between the weaned and non-weaned patient groups.

Countries

Turkey (Türkiye)

Outcome results