Changes in FeNO Value During Pulmonary Rehabilitation in Patients with Asthma

Change in Daily FeNO During Three Weeks of Inpatient Pulmonary Rehabilitation in Patients with Asthma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06751550

Acronym

Asthma FeNO

Enrollment

Registered

2024-12-30

Start date

2021-05-17

Completion date

2024-12-20

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma Bronchiale, Asthmatic Patients, Asthmatics

Keywords

FeNO, Fractional Exhaled Nitric Oxide

Brief summary

This study investigates the use of fractional exhaled nitric oxide (FeNO) measurement to monitor non-pharmacological therapy during a three-week inpatient rehabilitation programme for asthma patients. It compares FeNO levels (measured three times a day) with clinical parameters and quality of life to analyse daily fluctuations and the acute effect of exercise training on FeNO levels. As FeNO is a non-invasive biomarker of airway inflammation, this study aims to expand its role in therapy monitoring and explore its application in a rehabilitation setting.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* confirmed diagnosis of bronchial asthma (all disease severities) * Chronic Obstructive Pulmonary Disease (COPD) with an asthma component, where the asthma component plays a clinically relevant role * written informed consent

Exclusion criteria

* Chronic Obstructive Pulmonary Disease (COPD) as the primary disease * unability to perform FeNO measurement independently

Design outcomes

Primary

Measure	Time frame	Description
Fractional Exhaled Nitric Oxide (FeNO) at rest	From enrollment to the end of rehabilitation at 3 weeks. Daily measurements at 9AM; 1PM; 5PM	Measurement of FeNo will be done with the Vivatmo Me device (by Bosch Health Care Solutions GmbH)
Fractional Exhaled Nitric Oxide (FeNO) before/after exercise	From enrollment to the end of rehabilitation at 3 weeks, FeNO measurements will be done before and after a bicycle endurance training	Measurement of FeNo will be done with the Vivatmo Me device (by Bosch Health Care Solutions GmbH)

Secondary

Measure	Time frame	Description
Eosinophils	On admission and discharge from the 3-week rehabilitation programme	Eosinophils will be collected by venous blood sample. Unit: total number of cells per ul blood and percentage
C-reactive protein	On admission and discharge from the 3-week rehabilitation programme	C-reactive protein will be collected by venous blood sample. Unit: mg/liter
Asthma control	On admission and discharge from the 3-week rehabilitation programme	Assessed by Asthma Control Test (ACT)
6-minute walk test	On admission and discharge from the 3-week rehabilitation programme	This test will be performed according to the described standard of the American Thoracic Society and the European Respiratory Society 2014
Immunoglobulin E (IgE)	On admission and discharge from the 3-week rehabilitation programme	Immunoglobulin E will be collected by venous blood sample. Unit: ug/liter
Lung function	On admission and discharge from the 3-week rehabilitation programme	Forced expiratory flow in 1 second, will be measured by Bodyplethysmography

Countries

Germany

Outcome results