Development and Validation of a Clinical Risk Prediction Model for Early Acute Kidney Injury Within 48 Hours After Liver Transplantation

Development and Validation of a Clinical Risk Prediction Model for Early Acute Kidney Injury After Liver Transplantation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06750770

Enrollment

453

Registered

2024-12-27

Start date

2018-01-01

Completion date

2022-12-15

Last updated

2024-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Liver Transplantation, Model

Keywords

acute kidney injury, liver transplantation, model, validation

Brief summary

Acute kidney injury (AKI) is a common complication after liver transplantation, with an incidence of 12.7-95%. The occurrence of acute kidney injury after transplantation is related to the poor prognosis of patients, which significantly increases the length of hospital stay, hospitalization costs and mortality of patients. Early recognition of acute kidney injury after transplantation is of great significance. Therefore, by collecting preoperative and intraoperative variables, this study intends to establish and verify a clinical risk prediction model for early AKI after liver transplantation, in order to provide clinicians with a visual prediction tool to identify patients with high risk of early AKI after liver transplantation immediately after the operation, so as to start clinical intervention as soon as possible and improve the prognosis of patients.

Interventions

DIAGNOSTIC_TESTKDIGO CRITERIA

2012 KDIGO DIAGNOSTIC CRITERIA

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients who underwent liver transplantation in Beijing Tsinghua Changgung Hospital.

Exclusion criteria

* (1) under 18 years of age (2) post-renal transplant (3) liver combined with other organ transplants (4) preoperative requirement for renal replacement therapy (RRT) (5) patients with second or multiple liver transplants (6) preoperative estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73m2, and (7) patients with severe illness leading to termination of surgery.

Design outcomes

Primary

Measure	Time frame	Description
KDIGO criteria (Kidney Disease: Improving Global Outcomes) used to evaluate postoperative AKI in liver transplant patients.	48 hours post-surgery	Diagnosed according to 2012 KDIGO criteria: serum creatinine rise ≥50% or ≥26.5 µmol/L within 48 hours post-surgery. Baseline creatinine was the most recent preoperative value, with kidney function assessed by eGFR.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026