Major Depression
Conditions
Keywords
Major Depression Disorder, acupoint temperature, adolescent
Brief summary
Modern studies have confirmed that skin temperature changes at acupoints when the body is under pathological conditions. This suggests that changes in the thermal radiation characteristics of acupoints can objectively respond to the symptoms of a disease. In this study, the investigators first evaluated reproducibility of acupoint temperature measurement by IRT. Secondly, the investigators explored the thermal radiation characteristics of MDD-related acupoints, built the diagnostic model for adolescent depression severity and the diagnostic model for MDD in adolescents based on acupoint temperature. Our research findings will provide new ideas, methods and visualisations for early screening, auxiliary diagnosis and condition assessment of MDD in adolescents.
Detailed description
A total of 100 subjects were included, 60 adolescent with MDD (MDD group) and 40 healthy controls (HC group). All subjects accepted IRT detection.The random selection of 30 adolescent with MDD allowed the collection of the bilateral same name acupoint temperatures. Intra- and inter-observer reproducibility for the patients were examined in some randomly selected patients by 2 investigators and 2 investigators both made 2 independent measurements in a week. 30 MDD subjects were detected the bilateral same name acupoint temperatures.
Interventions
DIAGNOSTIC_TESTInfrared thermography
A thermograph (NEC InfRec R450, Avio Infrared Technologies Co., Ltd., Tokyo) was used to record thermal images. The infrared camera was fixed on a tripod 1 m away from the subject to ensure that no shaking movements or vibrations occurred during the recording of thermal images. MDD related acupoints on the inner and outer sides of the limbs were detected. Appropriate body position was selected according to the different parts to be detected. Using the automatic interval saving shooting mode, one thermal picture was taken at 10-s intervals, 3 pictures were taken for each subject.
Sponsors
Zhejiang Provincial Tongde Hospital
First People's Hospital of Hangzhou
Xiaomei Shao
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
12 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria for the healthy control participants: * 12years≤ age\<18 years; * SDS score \<53; * Adolescents with normal cognitive function can cooperate with the study; * Adolescents and guardians agree to the study plan and sign the informed consent form. Inclusion criteria for the major depression disorder participants: * 12years≤ age\<18 years; * Self-rating Depression Scale (SDS) score ≥ 53; * Language, cognition and communication ability are normal; * Patients and guardians agree to the study plan and sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acupoint emperature | Baseline | Temperature of acupoints was measured by infrared thermography (IRT). IRT was not be performed on female subjects during their menstrual and ovulatory periods. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Self-Rating Depression Scale (SDS) Scores | Baseline | The standard score is the total of all scores multiplied by 1.25 to the nearest whole number on this scale, which has 20 questions. A standard score below 53 is normal; 53-62 is mild depression; 63-72 is moderate depression; 72 or more is severe depression. |
Countries
China
Outcome results
None listed