Common Wart
Conditions
Brief summary
This study aims to evaluate the efficacy and safety of intralesional injections of candida antigen, polidocanol sclerotherapy and combined candida antigen with polidocanol in treatment of patients with common warts.
Detailed description
Warts are benign proliferations of skin and mucosa caused by the human papillomavirus . Currently, more than 100 types of human papillomavirus have been identified, which is a non-enveloped double-stranded, circular, supercoiled DNA virus enclosed in an icosahedral capsid and comprising 72capsomers Immunotherapy in wart treatment is a type of biological therapy that uses substances to stimulate the immune system to help the body fight infected cells. This includes topical agents as imiquimod, sineacatechins, and Intralesional immunotherapy which become more preferred treatment line for several types of warts, several injectable agents have been examined such as vitamin D3, interferon alpha 2B and skin test antigens such as the candida antigen and purified protein derivatives or systemic immunotherapy as zinc, cimetidine. Intralesional candida antigen has been successfully used in the treatment of warts with the potential advantages of promising efficacy, low cost, high safety profile, simple easy injection, association with distant response, absence of scarring and pigmentary changes and less pain than destructive therapies, and low or absent recurrence rates Treatments targeting and obliterating blood vessels such as pulsed dye laser and photodynamic therapy have been used in the treatment of common warts. Based on these observations, and the previous reports of the successful use of polidocanol in the treatment of various skin conditions with vascular components, the intralesional polidocanol therapy could be helpful in the treatment of common warts through the thrombotic occlusion and obliteration of blood vessels within the wart. The complete and partial cure rates after intralesional polidocanol 3% injection in plantar warts were 60% and 25%, respectively
Interventions
DRUGpolidacanol 3%
Aethoxysklerol 3%,60mg/ ml ampoule, kreussler pharma, Germany
BIOLOGICALcandida antigen
delayed type of hypersensitivity reaction is induced toward the injected antigen and the wart virus as well. This can increase the ability of the immune system to recognize and eradicate the human papillomavirus on various parts of the body and eliminate the necessity of local treatment for each wart
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age group: \>18years. * Confirmed diagnosis by clinical and dermoscopic examination of common wart will be made.
Exclusion criteria
* Patients who receive any treatment for wart in the last month before the study. * Patients with history of renal or liver disease. * Patients with any evidence of bleeding diathesis, vaso-occulusive or thrombo-embolic disorders. * Pregnant and lactating females. * Patients who receive immunosuppressive therapy. * Patients' refusal. * Patients with history or evidenced hypersensitivity to any component used in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| size of warts | session every 2 weeks until complete clearance of warts or for a maximum of 6 treatment sessions and one month after last session | measured by ruler) with photographic comparison at base line and before each session and one month after last session in relation to baseline lesion to detect response to therapy |
Countries
Egypt
Contacts
Primary ContactHeba S Osman
Backup ContactMohamed A Ali
Outcome results
None listed