Deep Learning-enhanced Personalized Monitoring of Aortic Stenosis - The DETECT-AS Prognostic Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06749132

Enrollment

210

Registered

2024-12-27

Start date

2026-04-01

Completion date

2028-08-31

Last updated

2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Stenosis

Keywords

aortic stenosis, artificial intelligence

Brief summary

This study will evaluate the validity of a digital biomarker score for precision risk stratification among older adults with aortic sclerosis or mild aortic stenosis (AS) at three US health systems.

Interventions

DIAGNOSTIC_TESTTransthoracic echocardiogram

All study participants will undergo a clinical transthoracic echocardiogram (TTE) performed by certified echocardiography technicians. The TTE includes standard transthoracic examination with acquisition of B-mode, color and spectral Doppler images and videos in line with standard echocardiographic guidelines.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age 65 years or older 2. Prior transthoracic echocardiogram within the past 2-3 years showing aortic sclerosis without stenosis or mild AS

Exclusion criteria

1. Opted out of research studies 2. Non-English speaking 3. Any echocardiogram within 24 months of medical record review. 4. Prior history of aortic valve replacement or repair, including transcatheter and surgical AVR with either a bioprosthetic or mechanical valve 5. Presence of implantable cardiac devices, including permanent cardiac pacer, implantable cardioverter-defibrillator, or left ventricular assist device 6. Prior heart transplant 7. History of dementia 8. Unable to attend study visit at echocardiogram lab within four years of most recent echocardiogram. 9. Documented life expectancy of \<1 year or current participation in hospice services

Design outcomes

Primary

Measure	Time frame	Description
Annualized change in AV Vmax in m/sec/years	From baseline TTE to TTE performed at enrollment	The primary outcome measure is the annualized change in AV Vmax in m/sec/years, defined as the absolute difference between the value on the enrollment and baseline echocardiogram measurement, divided by the time difference between the studies.

Countries

United States

Contacts

CONTACTRohan Khera, MD, MS

rohan.khera@yale.edu203-764-5885

PRINCIPAL_INVESTIGATORRohan Khera, MD, MS

Yale University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026