Colorectal Cancer
Conditions
Keywords
CRC, microbiome
Brief summary
Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries. It can be considered a marker of socioeconomic development and a marker of significant changes in food habits and lifestyle. In Egypt, CRC represents the seventh most common cancer. It is the third most reported cancer in males and the fifth most common cancer in females. microbiome dysbiosis may be involved in the pathogensis and thus pose a therapeutic target
Detailed description
Many reports suggested the role of westernized dietary lifestyles, including high consumption of red meats, animal fats, and cholesterol-rich foods, as well as smoking, decreased physical activity, obesity, diabetes, alcohol consumption, or smoking, in CRC development. These changes in lifestyle are called the external factors, which are now linked to changes in the inner gut microenvironments, mainly the microbiomes. Our aim is to investigate the the changes in microbiome profile in relation to clinical, pathological and lifestyle factors
Interventions
OTHERno intervention
no intervention
Sponsors
Heliopolis University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age of 40 years to 80 years * Patients with a newly diagnosed CRC
Exclusion criteria
* Patients with previously known CRC * Pregnancy or Lactation * Abdominal surgery within/up to 6 months prior to sample collection * Antibiotics, corticosteroids, or probiotics up to three months prior to sample collection * History of other types of cancer * Subjects on a special diet * Diabetes, liver, or kidney diseases * CRC patients who used enema or underwent colonoscopy up to one week before sample collection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The effect of food and lifestyle on microbiome | through study completion, an average of 1 year | correlation between food and lifestyle with microbiome profiles |
| microbiome profile and CRC pathogensis | through study completion, an average of 1 year | correlation between microbiome profile and CRC pathogensis |
Countries
Egypt
Outcome results
None listed