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Corneal Topography in Vernal Keratoconjunctivitis

the Effect of Vernal Keratoconjunctivitis on Corneal Topographic Profiles

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06746467
Enrollment
44
Registered
2024-12-24
Start date
2025-06-30
Completion date
2026-12-31
Last updated
2024-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconjunctivitis

Keywords

corneal topography on vkc

Brief summary

To evaluate the corneal topographic changes in VKC patients using Pentacam and prevalence of KC development in VKC.

Detailed description

Vernal keratoconjunctivitis (VKC) is a chronic allergic disease, with seasonal periods of exacerbation.VKC is characterized by itching, photophobia. white mucous discharge, lacrimation, foreign body sensation, and pain due to corneal involvement of shield ulcers. Corneal involvement in VKC involves injury to the superficial and basal epithelial layers and anterior stroma . Excessive eye rubbing and a slow release of matrix metalloproteinases penetrate the cornea in presence of chronic epithelial damage causing astigmatism and corneal ectasia . These changes may be undetected until advanced complications such as keratoconus(KC) with thinning and protrusion of cornea leading to myopia and astigmatism . These changes can be measured accurately by corneal topography, making it the gold standard in the screening of keratoconus and other corneal ectasias . Corneal topography is a method of computer-assisted examination of the cornea in which multiple concentric light rings are projected on cornea. Changes in corneal topography indices to be studied include changes in effective refeactivepower ,asphericity , corneal asymmetry index and visual performance . It is a non-invasive exploratory technique to analyse both qualitatively and quantitatively the morphology of the cornea . The Penta Cam is a cornea and anterior segment topography device, based on a rotating Scheimpflug camera. Its optical cross-sectional analysis that helps in imaging of anterior and posterior corneal surfaces which provides with fullpachymetric map and many other data such as corneal aberrometry and densitometry that allow early detection of ectasia.

Interventions

DEVICEpentacam

evaluate corneal changes by pentacam

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

clinical diagnosis of vernal keratoconjunctivitis -

Exclusion criteria

patients with corneal disease as corneal opacity, corneal dystrophy or degenerative changes patients with previous corneal surgery patients with ocular trauma. \-

Design outcomes

Primary

MeasureTime frame
evaluate the corneal topographic changes in VKC patients using Pentacam1 year

Secondary

MeasureTime frame
prevalence of KC development in VKC1 year

Countries

Egypt

Contacts

Primary Contactmonica basem fayez, doctor
Monicabasem668@gmail.com+201202961139
Backup Contactdalia mohamed mohamed, professer
+201223212962

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026