Carcinoma in Situ
Conditions
Brief summary
This study investigates the role of Magnetic Resonance Imaging (MRI) in detecting Ductal Carcinoma in situ (DCIS) in high-risk breast cancer patients.
Detailed description
Improved detection rates of DCIS in high-risk patients. Enhanced diagnostic accuracy, reducing false positives and negatives. Ductal Carcinoma in situ (DCIS) is a non-invasive breast cancer where abnormal cells are confined to the milk ducts. The Breast Imaging Reporting and Data System (BI-RADS) is a standardized scoring system used to classify breast imaging findings. Scores range from 0 (incomplete) to 6 (known biopsy-proven malignancy).
Interventions
DIAGNOSTIC_TESTMagnetic Resonance Imaging (MRI)
To Evaluate the breast Magnetic Resonance Imaging (MRI) in detecting Ductal Carcinoma In Situ (DCIS) lesions among high-risk breast cancer patients while keeping the histopathology as a GOLD standard
Sponsors
Superior University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* High-risk breast cancer patients with a family history of breast cancer or genetic predispositions (e.g., BRCA mutations). * Patients aged 30-65 years. * Patients willing to undergo breast MRI screening for DCIS detection.
Exclusion criteria
* Patients with contraindications to MRI imaging (e.g., pacemakers, claustrophobia). * Patients with a history of prior breast surgery or interventions that may interfere with imaging interpretation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity & specificity | 12 Months | sensitivity & specificity of MRI in detecting DCIS |
| BIRADS scores | 12 Months | BIRADS scores will be used to evaluate the diagnostic accuracy of MRI in detecting DCIS |
Countries
Pakistan
Outcome results
None listed