Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery

Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery; A Multicentered Cross-Sectional Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06744088

Enrollment

200

Registered

2024-12-20

Start date

2024-02-28

Completion date

2025-03-01

Last updated

2024-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Events

Brief summary

Introduction: Modern cardiac surgery prioritizes myocardial protection, incorporating various strategies including cardioplegia to preserve heart function during surgery. The Del Nido (DN) cardioplegia solution, initially for pediatric use, shows promise in adult surgeries due to its longer protection duration and reduced re-dosing needs. However, its efficacy in adults remains under-researched.

Detailed description

This study aims to evaluate the clinical outcomes of modified Del Nido cardioplegia in adult and pediatric cardiac surgeries, comparing intraoperative and postoperative metrics to provide evidence on its efficacy and safety. To assess the clinical outcomes of modified Del Nido cardioplegia in cardiac surgeries across different age groups, focusing on myocardial protection, hemodynamic stability, surgical outcomes, recovery, and complications.

Interventions

COMBINATION_PRODUCTDel Nido cardioplegia

To assess the clinical outcomes of modified Del Nido cardioplegia in cardiac surgeries across different age groups,

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 60 Years

Healthy volunteers

Inclusion criteria

* All Pediatric patients with congenital heart diseases. * Individuals who are capable of giving their informed permission; * Stable patients undergoing surgical procedures that involve cardiopulmonary bypass and cardiac arrest; * isolated CABG surgery, or simultaneous CABG; * isolated single-valve surgery or multiple value procedures.

Exclusion criteria

* Previous cardiac surgery * Patients with preoperative inotropic pharmacologic support * Patients receiving preoperative mechanical circulatory support, * Patients with an implanted pacemaker or implantable cardioverter-defibrillator, * Patients undergoing cardiac surgical procedures * Patients who underwent off-pump or beating heart CABGs * Ventilation for the night was scheduled because of severe pulmonary arterial hypertension. * mediastinal drain causing a delay in extubation, or the need to reopen for bleeding or tamponade.

Design outcomes

Primary

Measure	Time frame
the Bypass time	up to 12 Months
postoperative mortality	12 Months

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026