Cataract, Myopia
Conditions
Keywords
antioxidants
Brief summary
This trial hypothesized that novel laser refractive surgery techniques (LASIK, KLEx) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative stress generated by the surgical procedure. It is also intended to verify whether the new laser technology is necessary for clinical use in groups with low antioxidant activity through the detection of antioxidant activity in the eyes of patients.
Detailed description
Simultaneously measure total reactive oxygen species (ROS), antioxidant capacity (TAC) and ascorbic acid (AA) in aqueous humor (cataract surgery only) or tears. All patients underwent the same examination at our institution, including uncorrected visual acuity (UCVA), intraocular pressure (IOP), as well as central corneal thickness (CCT) with pneumatic tonometer, apparent refraction with autorefractor, and corneal curvature with keratometer. The axial length (AXL), anterior chamber depth (ACD) and lens thickness (LT) were measured by optical biometer.
Interventions
None listed
Sponsors
Taipei Nobel Eye Clinic
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* at least 20 years old * corneal refractive surgery or cataract surgery patients
Exclusion criteria
* patients with eye infections * presence of severe retinal disease * presence of severe eye injury or severe ptosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ROS in aqueous humor at the next day | Before the operation and one day after surgery. | Change of Reactive Oxygen Species (ROS) in aqueous humor from Baseline to one day after surgery |
| ROS in tears at 1 month | Before the operation and 1 month after surgery. | Change of Reactive Oxygen Species (ROS) from Baseline to 1 month after surgery. |
| ROS in tears at 2 months | Before the operation and 2 months after surgery. | Change of Reactive Oxygen Species (ROS) from Baseline to 2 moths after surgery. |
| ROS in tears at 3 months | Before the operation and 3 months after surgery. | Change of Reactive Oxygen Species (ROS) from Baseline to 3 months after surgery. |
| TAC in aqueous humor at the next day | Before the operation and one day after surgery. | Change of Total Antioxidant Capacity (TAC) in aqueous humor from Baseline to one day after surgery |
| AA in aqueous humor at the next day | Before the operation and one day after surgery. | Change of Ascorbic Acid (AA) in aqueous humor from Baseline to one day after surgery |
| TAC in tears at 1 week | Before the operation and 1 week after surgery. | Change of Total Antioxidant Capacity (TAC) from Baseline to 1 week after surgery. |
| TAC in tears at 1 month | Before the operation and 1 month after surgery. | Change of Total Antioxidant Capacity (TAC) from Baseline to 1 month after surgery. |
| TAC in tears at 2 months | Before the operation and 2 months after surgery. | Change of Total Antioxidant Capacity (TAC) from Baseline to 2 months after surgery. |
| TAC in tears at 3 months | Before the operation and 3 months after surgery. | Change of Total Antioxidant Capacity (TAC) from Baseline to 3 months after surgery. |
| AA in tears at 1 week | Before the operation and 1 week after surgery. | Change of Ascorbic Acid (AA) from Baseline to 1 week after surgery. |
| AA in tears at 1 month | Before the operation and 1 month after surgery. | Change of Ascorbic Acid (AA) from Baseline to 1 month after surgery. |
| AA in tears at 2 months | Before the operation and 2 months after surgery. | Change of Ascorbic Acid (AA) from Baseline to 2 months after surgery. |
| AA in tears at 3 months | Before the operation and 3 months after surgery. | Change of Ascorbic Acid (AA) from Baseline to 3 months after surgery. |
| ROS in tears at 1 week | Before the operation and 1 week after surgery. | Change of Reactive Oxygen Species (ROS) from Baseline to 1 week after surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| UCVA at 1 week | 1 week after surgery | Examination of uncorrected visual acuity (UCVA) |
| UCVA at 1 month | 1 month after surgery | Examination of uncorrected visual acuity (UCVA) |
| UCVA at 2 months | 2 months after surgery | Examination of uncorrected visual acuity (UCVA) |
| UCVA at 3 months | 3 months after surgery | Examination of uncorrected visual acuity (UCVA) |
| BCVA | Before surgery | Examination of best corrected visual acuity (BCVA) |
Countries
Taiwan
Contacts
Primary ContactHung-Chi Chen, PhD
Backup ContactChia-Yi Li, MD
Outcome results
None listed