Cerebrospinal Fluid, Healthy Subjects or Volunteers
Conditions
Brief summary
This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord). The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). This will enable us to develop and validate a numerical model of the SAS.
Interventions
OTHERMRI Contrast
Pass a Phase Contrast MRI. No injection required.
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 years at the time of agreement * Free subject, without guardianship or curatorship or subordination * Patients benefiting from a Social Security scheme or benefiting from it through a third party * Informed consent signed by the patient after clear and complete information about the study
Exclusion criteria
* 3T MRI contraindications (pacemaker, cochlear implant, metallic splinter, etc) * History of neurological pathology * Previous operations involving the central nervous system (spinal surgery, neurological surgery, etc.) * Current pathology or treatment that may interfere with the CSF or subarachnoid spaces (CSF dysregulation, disc herniation, hydrocephalus, Chiari malformation, etc.) * Concurrent participation in another clinical research study * Persons not covered by Social Security or not covered by Social Security through a third party * Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, adults under legal protection * Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1) | Time PC-MRI will be around 60min | Displacement velocities of CSF will be obtain by Phase Contrats MRI. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Using morphological MRI to model a digital twin | Time PC-MRI will be around 60min | Comparison of velocity fields for each measurement section plane |
| To evaluate the velocity displacement of blood about 2 planes (intracranial plane, C2-C3) | Time PC-MRI will be around 60min | Displacement velocities of blood will be obtain by Phase Contrats MRI. |
Countries
France
Outcome results
None listed