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Application of DCE-MRI Based on 4D FreeBreathing in Predicting the Efficacy of Immune and Targeted Therapy in Lung Cancer

Application of DCE-MRI Based on 4D FreeBreathing in Predicting the Efficacy of Immune and Targeted Therapy in Lung Cancer

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06742021
Enrollment
195
Registered
2024-12-19
Start date
2024-11-11
Completion date
2026-07-31
Last updated
2024-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Brief summary

This study aims to address the challenge of predicting the efficacy of targeted and immunotherapy in lung cancer patients. By utilizing two DCE-MRI images-one before treatment and one after one treatment cycle-along with the patients' clinical and pathological information, we aim to achieve accurate prediction of the therapeutic efficacy of targeted and immunotherapy in lung cancer patients.

Interventions

DIAGNOSTIC_TESTApplication Value of MRI Imaging in Treatment Decision-Making for Lung Cancer

Chest MRI scans outside of the standard treatment protocol

Sponsors

Yunnan Cancer Hospital
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

1. Tumor size greater than 2 cm 2. Age between 18 and 75 years

Exclusion criteria

1. Presence of MRI contraindications (e.g., metal implants, pacemaker implantation, etc.) 2. Allergy to gadolinium contrast agents 3. Lesions difficult to delineate on images due to conditions such as atelectasis or diffuse lesions

Design outcomes

Primary

MeasureTime frameDescription
Tumor treatment response evaluationwithin one week before treatment and two weeks after treatment completionThis study aims to evaluate tumor treatment response using the RECIST V1.1 criteria, based on CT images taken within one week before treatment and two weeks after treatment completion.

Countries

China

Contacts

Primary Contactzhihui shi
3332105746@qq.com15087838660
Backup ContactZhenhui Li
lizhenhui@kmmu.edu.cn13698736132

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026