ARDS
Conditions
Brief summary
Investigating the Impact of Combined Inhaled Nitric Oxide and Prone Positioning on the Efficacy in ARDS Patients
Interventions
PROCEDUREinhaled nitric oxide combined with prone position ventilation
inhaled nitric oxide combined with prone position ventilation
Sponsors
Northern Jiangsu People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18-80 years; 2. Patients with moderate to severe ARDS on mechanical ventilation
Exclusion criteria
1. Patients with severe asthma or acute exacerbation of chronic obstructive pulmonary disease (COPD), lung tumors, post-lung resection, and post-lung transplantation. 2. Patients with hemodynamic instability requiring vasopressor support: dopamine or dobutamine \>15 µg/kg/min, norepinephrine \>0.3 µg/kg/min. 3. Cardiogenic pulmonary edema. 4. Patients with severe facial deformities, facial trauma, or severe thoracoabdominal trauma that precludes prone positioning ventilation. 5. Mid to late pregnancy. 6. Patients with a history of malignancy or other irreversible diseases/conditions, including those in the terminal stage. 7. Patients expected to be discharged soon or requiring invasive mechanical ventilation for less than 24 hours. 8. Patients currently participating in other studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intratidal gas distribution | 12 hours |
Countries
China
Contacts
Primary ContactChuanqing Zhang Study Director
Outcome results
None listed