Skeletal Muscle Index and a Neuromuscular Blocking Agent

Relationship Between Skeletal Muscle Index in Preoperative Computed Tomography and a Neuromuscular Blocking Agent Dose Required for Maintaining Deep Neuromuscular Blockage: a Prospective Observational Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06740877

Enrollment

Registered

2024-12-18

Start date

2025-05-09

Completion date

2026-06-01

Last updated

2026-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuromuscular Blockade

Brief summary

With the recent development of image analysis, it has become possible to measure the skeletal muscle index representing the subject's muscle mass from preoperative computed tomography (CT) images. Therefore, in this study, the investigators quantify the skeletal muscle index from preoperative CT images and analyze the correlation with the dose of neuromuscular blocking agent, rocuronium, required for maintaining deep neuromuscular blockade.

Detailed description

Deep neuromuscular blockade improves the condition of surgeon's surgical field during the surgery and reduces the acute postoperative pain. The dosage of neuromuscular blocking agent has been usually administered according to the patient's actual body weight, but even with the same body weight, the ratio of muscle to fat varies from individual to individual, and there are many differences depending on age, gender, and exercise level. Therefore, if the dose of neuromuscular blocking agent is administered according to actual body weight, additional doses may be required due to insufficient neuromuscular blockade, or excessive doses may occur. However, it was difficult to quantify the muscle mass, with the recent development of image analysis, it has become possible to measure the skeletal muscle index representing the subject's muscle mass from preoperative computed tomography (CT) images. Therefore, in this study, the investigators quantify the skeletal muscle index from preoperative CT images and analyze the correlation with the dose of neuromuscular blocking agent, rocuronium, required for maintaining deep neuromuscular blockade.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 85 Years

Inclusion criteria

* Those who voluntarily agreed and signed the written consent form before participating in the study * American Society of Anesthesiologists physical class (ASA class) 1-3 * Patients scheduled for elective colon surgery under general anesthesia * Patients undergoing abdominal computed tomography for routine preoperative preparation

Exclusion criteria

* Pregnant women * Decreased renal function (GFR\<60mL/min/1.73m2). * Patients taking drugs that affect deep neuromuscular blockade * Patients with a history of neuromuscular and muscle disorders

Design outcomes

Primary

Measure	Time frame	Description
Skeletal Muscle index	preoperative period	Muscle amount

Countries

South Korea

Contacts

PRINCIPAL_INVESTIGATORInsun Park, M.D./Ph.D.

assistant professor

Outcome results