Healthy
Conditions
Keywords
Muscle damage, Single nucleotide polymorphism, exercise
Brief summary
The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.
Detailed description
Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.
Interventions
OTHERExercise
Muscle induced-damage eccentric exercise
Sponsors
Lille University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Intervention model
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female * Aged between 18 and 35 * Weighing more than 50 kg * Member of a sports club affiliated to an Olympic federation * Socially insured * Willing to comply with all study procedures and duration of the study
Exclusion criteria
* Medical history contraindicating sporting activities * Current medical treatment * Not a member of a sports club affiliated to an Olympic federation * Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The association between single nucleotide polymorphisms and exercise induced blood creatine kinase variation | Evolution of kinetics from Day 0 to Day 3 post experiment | Association between blood creatine kinase level variations and single nucleotide polymorphisms. The Outcome Measure in this study is focused on the variation in plasma CPK levels following an exercise inducing muscle damage. The result is expressed as a change in plasma CPK concentration, measured in units per liter (U/L). This single measurement is used to investigate its association with genetic polymorphisms. Therefore a regression analysis will be performed to identify the association. This study is exploratory and the genetic polymorphisms are not pre-identified but will be investigated through a comprehensive analysis. |
Countries
France
Outcome results
None listed