Comparison of Antinociceptive Effects of Ketamine and Magnesium Used for Sedation in Hysteroscopy Cases

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06739460

Enrollment

120

Registered

2024-12-18

Start date

2024-12-10

Completion date

2025-01-15

Last updated

2024-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysteroscopy

Keywords

Magnesium, Sedation, Hysteroscopi, Opioid, Pain

Brief summary

This study aims to compare the antinociceptive effects of ketamine and magnesium used in addition to midazolam, fentanyl, propofol and remifentanil agents preferred in hysteroscopy cases. It is conducted to observe the effect of ketamine and magnesium use on total additional propofol doses and additional remifentanil doses.

Detailed description

Sedation is generally preferred in hysteroscopy cases. The most commonly used intravenous drugs are midazolam, fentanyl, propofol and remifentanil. Multimodal analgesia, which is intended to be provided in hysteroscopy cases, is a strategy that includes the use of two or more analgesic agents and techniques to provide adequate analgesia; and aims to minimize side effects such as bradycardia, hypotension, respiratory depression, pruritus, and postoperative nausea and vomiting. Multimodal analgesia improves patient and surgical comfort by applying additional drugs to existing agents, reduces postoperative complications, and thus helps to shorten hospital stays and reduce costs. Whether magnesium contributes to this multimodal analgesia will be investigated observationally, based on its antinociceptive effects.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

1. ASA I-II patients 2. Patients aged 18-55 3. Patients undergoing hysteroscopy

Exclusion criteria

1. Patients who develop surgical complications during hysteroscopy 2. Patients with cardiovascular failure (ejection fraction \<40%, patients with atrioventricular conduction disorder 3. Patients with history of cerebrovascular disease 4. Liver dysfunction (transaminases above normal level), Renal failure (creatine \> 150 μmol/L), 5. Preoperative opioid use 6. History of neuromuscular disease 7. History of drug or alcohol abuse 8. Patients who develop the need for endotracheal intubation

Design outcomes

Primary

Measure	Time frame	Description
Antinociceptive effects of ketamine and magnesium	During the hysteroscopic procedures.	Observe the effect of ketamine and magnesium use on total additional doses of propofol and additional doses of remifentanil.

Countries

Turkey (Türkiye)

Outcome results