The Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Ankylosing Spondylitis

Investigation of the Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Patients With Ankylosing Spondylitis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06739369

Enrollment

Registered

2024-12-18

Start date

2025-08-06

Completion date

2026-12-31

Last updated

2025-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ankylosing Spondylitis (AS)

Brief summary

The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of ankylosing spondylitis according to ASAS diagnostic criteria * Being aged 18-65 * Stable medication use for at least 3 months * Voluntary participation in the study

Exclusion criteria

* Having uncontrolled cardiopulmonary disease * Being pregnant * Having undergone recent surgery * Presence of malignancy * Failure to perform to assessments

Design outcomes

Primary

Measure	Time frame	Description
Muscle function	1st day	It will be evaluated with one-minute sit to stand test
Arterial stiffness	1st day	It will be evaluated with brachial pulse waves.
Respiratory muscle strength	1st day	Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) will be measured using a portable mouth pressure device.
Respiratory muscle endurance	1st day	This will be evaluated with increased workload testing.
Exercise capacity	1st day	Exercise capacity will be assessed with 6 minute walk test.
Peripheral muscle strength	1st day	Hand grip strength will be assessed with a grip dynamometer.

Secondary

Measure	Time frame	Description
Physical activity	1st day	Physical activity level will be evaluated using International Physical Activity Questionnaire-Short form
Forced vital capacity	1st day	Forced vital capacity (FVC) will be assessed using spirometry.
Forced expiratory volume in one second	1st day	Forced expiratory volume in one second (FEV1) will be assessed using spirometry.
Forced expiratory volume in one second/forced vital capacity ratio	1st day	Forced expiratory volume in one second/forced vital capacity ratio will be assessed using spirometry.
Peak expiratory flow	1st day	Peak expiratory flow (PEF) will be assessed using spirometry.
Forced mid-expiratory flow	1st day	Forced mid-expiratory flow (FEF25-75) will be assessed using spirometry.

Countries

Turkey (Türkiye)

Contacts

Primary ContactMerve Firat

mervefirat@ahievran.edu.tr+90 850 441 02 44

Outcome results