Lung Cancer - Non Small Cell
Conditions
Keywords
NSCLC, ML, DFS
Brief summary
The investigators retrospectively collected the participants with stage I non-small cell lung cancer (NSCLC) patients resected between January 2010 to December 2020 for training and internal validation. The Clinical data, preoperative clinical information, laboratory results and CT images were collected. The investigators also collected the disease-free survival time. On the Deepwise multi-modal research platform, the images were semi-automatically segmented and expanded outward by 3mm to obtain the peritumor tissue. PyRadiomics was used to extract the radiomic features. LASSOcox and rsf were used to select the features. we developed a machine learning-based integrative prognostic model that utilizes radiomic and pathological variables as input using LOOCV framework. And it was further tested on the internal and external cohorts. Discrimination was assessed by using the C-index and area under the receiver operating characteristic curve (AUC), IBS, DCA.
Interventions
OTHERCT radiomic analysis
Radiomic features of tumor and peritumor tissue
Sponsors
Jinling Hospital, China
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
patients with stage I NSCLC (ninth AJCC edition) who underwent curative R0 resections between January 2010 and December 2020 -
Exclusion criteria
1. absence of enhanced CT 2. history of lung cancer or synchronous lung cancers 3. follow-up records ≤3 Months 4. carcinoma in situ (CIS) or minimally invasive NSCLC 5. death within 30 days of surgery 6. no pathological slides or reports
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| DFS（Disease-free survival） | Record from the date of surgery to the date of recurrence or death from any cause, whichever comes first, and assess up to a maximum of 5 years. | DFS was defined as the duration from the date of primary surgery to the first occurrence of recurrence or death from any cause. |
Countries
China
Outcome results
None listed