Chronic Obstructive Pulmonary Diseases, Sarcopenic Obesity
Conditions
Brief summary
Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults. Previous research has shown that increased dietary intake of total and plant-based protein is associated with a lower risk of sarcopenic obesity, using data from the EPIC Norfolk study. Furthermore, a systematic review and meta-analysis showed that having sarcopenic obesity was associated with significantly impaired lung function outcomes. Other research has shown that increased intake of dietary protein leads to a better treatment outcome for respiratory diseases. The aim of this pilot observational study is to investigate, in more detail, the relationship between the quantity and source of dietary protein intake, the prevalence of sarcopenic obesity, and lung function, in a small cohort of older female participants with COPD. The study will also consider the role of inflammation in relation to sarcopenic obesity and lung function outcomes. This study will help to improve the understanding of the relationship between sarcopenic obesity and lung function outcomes, and how dietary protein intake and inflammation can affect this relationship and each of the outcomes.
Interventions
OTHERthe relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes
Primary Objective The primary objective is to measure the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes, in older female participants with clinically diagnosed COPD. Secondary Objectives The secondary objective is to investigate whether the level of inflammation (plasma CRP) is associated with the intake of total, plant-based and animal-based protein, with the prevalence of sarcopenic obesity, and with lung function outcomes.
Sponsors
University of Aberdeen
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Women. * Clinically diagnosed with COPD. * Aged 55 years or older.
Exclusion criteria
* Male. * Women who are 54 years or younger. * Those who have dementia. * Unable to read or write in English. * Unable to attend the Human Intervention Studies Unit. * Those within one year life expectancy. * Those who have cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association between dietary protein and the prevalence of sarcopenic obesity | through study completion, an average of 1 year | Association between dietary intake of total, plant-based and animal-based protein and the prevalence of sarcopenic obesity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between dietary protein and lung functions outcomes | through study completion, an average of 1 year | Association between dietary intake of total, plant-based and animal-based protein and lung functions outcomes (Forced Vital Capacity (FVC), Forced Expiratory Volume in The First Second(FEV1), and The Ratio of Forced Expiratory Volume in The First Second to Forced Vital Capacity (FEV1/FVC ratio)). |
Countries
United Kingdom
Outcome results
None listed