Non-Alcoholic Fatty Liver Disease
Conditions
Brief summary
The purpose of this study is to quantitatively assess the changes in liver fat content in cancer patients before and after treatment. The main questions it aims to answer are:How does the liver fat fraction change before and after chemotherapy? In this study, patients undergoing mDixon Quant scanning are subjected to fully automated segmentation and measurement of liver fat content using artificial intelligence.
Detailed description
Regarding the extraction of liver fat fraction, the traditional axial ROI method involves selecting several regions of interest (ROIs) at the largest cross-sectional level or across multiple continuous sections, and taking the average value as the whole-liver fat fraction. This method is complex, time-consuming, and cannot obtain the whole-liver fat fraction. In this study, a threshold extraction method is used to obtain the whole-liver fat fraction, enabling a 2D-to-3D conversion, which is more time-efficient and labor-saving, and provides a more accurate measurement.
Interventions
DRUGNeoadjuvant chemotherapy
Neoadjuvant chemotherapy
Sponsors
Yunnan Cancer Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. CT/B ultrasound showed no fatty liver 2. No MRI contraindications, including pacemaker, stent, metal implant, or claustrophobia 3. Received neoadjuvant/adjuvant chemotherapy
Exclusion criteria
1. Missing follow-up information 2. Liver lesions (metastases, hemangioma, etc.) 3. Poor image quality
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extract the whole liver fat fraction | one year | Extract the whole liver fat fraction using the threshold extraction method. |
Countries
China
Contacts
Primary ContactLizhu Liu, Graduate
Backup ContactZhenhui Li, MD
Outcome results
None listed