Papillary Thyroid Cancer
Conditions
Brief summary
To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma
Detailed description
To evaluate and predict long-term clinical outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma by a multicenter study
Interventions
PROCEDUREultrasound-guided thermal ablation
ultrasound-guided thermal ablation to treat tumor
Sponsors
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. patients age between 18 and 80 year old, both sex 2. papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration 3. the largest diameter ≤2.0 cm 4. no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, neck and chest CT 5. follow-up period ≥12 months
Exclusion criteria
1. patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy 2. history of neck radiation 3. coagulation disorder, serious heart, respiratory, liver, or renal failure 4. dysfunction of the vocal cord on the opposite side
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| rate of disease progression | through study completion, an average of 6 months | cervical lymph node metastases, recurrent tumors and persistent tumors confirmed by pathology |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of complications | 1 week | complications of ablation |
| Rate of tumor disappearance | through study completion, an average of 6 months | complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound |
| Rate of volume reduction | through study completion, an average of 6 months | volume reduction of tumor after ablation on ultrasound and contrast-enhanced ultrasound |
| rate of change of thyroid function | through study completion, an average of 6 months | thyroid function test, including free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroid peroxidase antibody and anti-thyroglobulin antibodies |
| rate of delayed surgery | through study completion, an average of 1 year | patients underwent surgery after ablation because of anxiety |
Countries
China
Contacts
Primary ContactLin Yan, MD
Outcome results
None listed