Vitiligo
Conditions
Keywords
biomarker, vitiligo
Brief summary
The goal of this case-control study is to evaluate the possible applicability of CXCL10, CXCL9, CCL20, and homocysteine as biomarkers of disease activity in vitiligo patients and to compare the levels of these markers with those in healthy controls.
Detailed description
The diagnosis and prognosis assessment in patients with vitiligo are essentially clinical. There are still no validated and established serological markers to objectively assist in defining disease activity. Objective: To evaluate the potential use of the biomarkers CXCL9, CXCL10, CCL20, S100B, and homocysteine to identify disease activity in vitiligo, comparing their values with controls. Methods: A case-control study using previously collected peripheral blood samples from patients aged 18 years or older with a diagnosis of vitiligo and from controls without the disease. The project was approved by the institution's ethics committee. Tests were conducted using ELISA and Luminex kits to measure CXCL9, CXCL10, CCL20, and S100B. For homocysteine, the chemiluminescence method was used.
Interventions
None listed
Sponsors
Hospital de Clinicas de Porto Alegre
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Vitiligo * Older than 18 years
Exclusion criteria
* Not having diagnosis of vitiligo * Less than 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biomarkers levels | through study completion, an average of 2 year | Assessment of the biomarkers levels in vitiligo group and group control |
Countries
Brazil
Outcome results
None listed