Long-term Renal Prognosis of Neonatal Acute Kidney Injury

Long-term Renal Prognosis of Neonatal Acute Kidney Injury: A Multicenter, Prospective Cohort Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06731205

Enrollment

1852

Registered

2024-12-12

Start date

2025-01-01

Completion date

2028-12-31

Last updated

2024-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal Acute Kidney Injury

Keywords

Neonatal Acute Kidney Injury, Long-Term Prognosis, Prognosis and Predictive Factors, Biomarkers

Brief summary

The goal of this observational study is to conduct a multicenter, prospective neonatal acute kidney injury (AKI) follow-up cohort to describe the clinical characteristics of chronic kidney disease (CKD) in AKI cases within 1 year of follow-up and screen for effective biomarkers that can early warn of CKD progression. Ultimately, a neonatal AKI adverse prognosis warning model based on multidimensional data will be established to provide new data and new models for CKD management.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 28 Days

Healthy volunteers

Inclusion criteria

* Delivered in this hospital and subsequently admitted to the NICU during the study period; * Diagnosed with neonatal AKI according to the 2015 KDIGO neonatal AKI criteria; * Age \<28 days.

Exclusion criteria

* Severe hydronephrosis diagnosed by prenatal renal ultrasound; * Patients with congenital urinary malformations, including solitary kidney, cystic dysplasia, multicystic dysplastic kidney, renal dysplasia, and obstructive uropathy; * Newborns who required congenital heart surgery within the first 7 days after birth; * Newborns whose mothers had a history of renal failure; * Death within 48 hours after birth; * Other genetic syndromes or medical conditions were not eligible for inclusion according to the attending neonatologist's judgment.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of chronic kidney disease (CKD)	1-3 years	The incidence of CKD stage 3-5 (eGFR \< 60 ml/min) within 1, 2, and 3 years of follow-up

Secondary

Measure	Time frame
Mortality	1-3 years
Incidence of renal replacement therapy	1-3 years
Incidence of proteinuria	1-3 years
Incidence of height retardation	1-3 years
Incidence of hypertension	1-3 years

Contacts

Primary ContactXia Gao

gaoxiagz@vip.163.com86-020-38370569

Outcome results