Autonomic Nervous System Imbalance
Conditions
Keywords
Vagus Nerve Stimulations, Trigeminal Nerve Stimulations
Brief summary
The aim of this study was to compare the results between transcutaneous auricular vagus nerve stimulation and trigeminal nerve stimulation with the results obtained from heart rate variability, pulse and blood pressure measurements and to reveal which method is more effective in autonomic nervous system neuromodulation. Hypotheses of the study: H0: Vagus nerve stimulation is more effective than trigeminal nerve simulation in terms of heart rate variability. H1: Trigeminal nerve stimulation is more effective than vagus nerve simulation in terms of heart rate variability.
Detailed description
In this study, 80 healthy participants (40 males, 40 females) aged between 20-50 years were randomized (www.randomizer.org) into four groups by computer software. After randomisation, one group was received transcutaneous vagus nerve stimulation inside the ear, while the other group was received trigeminal nerve stimulation above the ear.The third group received sham transcutaneous vagus nerve stimulation and the fourth group received sham trigeminal nerve simulation. Heart rate variability, pulse rate and blood pressure measurements were performed to determine which stimulation method is more effective. Heart rate variability was analysed with Kubios HRV programme after the 5-minute short measurement method. SNS, PNS and Stress Index and LF, HF and LF/HF parameters were evaluated in heart rate variability sub-parameters.
Interventions
DEVICETranscutaneous Auricular Vagus Nerve Stimulation
Stimulation of the vagus nerve through the tragus and concha in the ear
Stimulation of the trigeminal nerve via the auriculotemporal nerve with a clip electrode from the upper auricle
Sponsors
Bahçeşehir University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SCREENING
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* To be 18 years of age or older, * Not having any acute or chronic disease.
Exclusion criteria
* Having any acute or chronic disease, * Having previously undergone vagus nerve stimulation or trigeminal nerve stimulation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart Rate Variability | Pre-intervention and immediately after the intervention | 5 minutes of heart rate variability was measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Systolic and Diastolic Blood Pressure | Pre-intervention and immediately after the intervention | Systolic and diastolic blood pressure was measured with an electronic blood pressure monitor. |
Countries
Turkey (Türkiye)
Outcome results
None listed