Pleural Effusion Disorder
Conditions
Brief summary
Single-arm pilot trial of the use of intrapleural saline irrigation to treat retained pleural infections for patients with contraindications to standard of care intrapleural enzymatic therapy.
Interventions
DEVICEof intrapleural saline irrigation with CLR irrigator
patients will have a CLRTM port and CLRTM irrigator (CLR Medical, Calverton, MD, USA) added to their chest tube and atrium circuit to facilitate pleural irrigation.
Sponsors
Beth Israel Deaconess Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Retained pleural effusion identified via bedside ultrasound within the first 24 hours after chest tube insertion * Patient is contraindicated from receiving intrapleural enzymatic therapy within the first 24 hours after chest tube insertion
Exclusion criteria
* Non-infectious cause of pleural fluid analysis findings listed above identified (e.g. malignancy) * Post-procedural empyema or complicated parapneumonic effusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiographic improvement (reduction in the ammount of pleural effusion messured in centimeters) by bed side ultrasound day 1,2,3,4,5. | Daily for 8 days |
Countries
United States
Contacts
CONTACTChristine Conley
Outcome results
None listed