Heart Failure
Conditions
Keywords
heart failure, influenza, vaccination
Brief summary
In patients with heart failure (HF), influenza vaccination should be considered to prevent HF hospitalizations. However, vaccination rates among patients with HF are low, in part because of subjective but common concerns about whether patients with such severe disease should be vaccinated. In this randomized, open-label study, we will investigate whether influenza vaccination before discharge in patients stabilized after cardiac decompensation is safe and improves outcomes over a 6-month follow-up period.
Interventions
BIOLOGICALInfluenza vaccination
Influenza vaccination pre-discharge in patients hospitalized due to heart failure exacerbation
Sponsors
Wroclaw Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* informed consent to participate in the study * hospitalization (unplanned) due to exacerbation (decompensation) of heart failure * planned discharge within the next 48 hours due to completion of hospital treatment * no current (2024/25 season) influenza vaccination.
Exclusion criteria
* severe post-vaccination reaction during influenza vaccination in any previous influenza season * hypersensitivity to any of the components of the vaccine planned to be administered * discharge to another hospital for continued treatment or discharge to a nursing home * antibiotic therapy among the drugs recommended for taking after hospitalization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary composite endpoint - cardiovascular death, heart failure hospitalization or infection | 6 months |
Countries
Poland
Outcome results
None listed