Dry Eye Disease With Isotretinoin ISOTRETINOIN

Digital Assessment of Dry Eye Diseases in Acne Vulgaris Patients Receiving Isotretinoin Therapy

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06725290

Enrollment

Registered

2024-12-10

Start date

2025-06-01

Completion date

2025-09-30

Last updated

2025-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne Vulgaris

Brief summary

The study aims to explore the effects of isotretinoin therapy on the dry eye parameters in acne vulgaris patients & determine if it is dose-dependent or not.

Detailed description

To measure the tear film, the eye lid thickness, the meibomian gland function and to do objective tests for comparison

Interventions

DIAGNOSTIC_TESTOcular Surface Disease Index (OSDI) questionnaire

The OSDI is a validated, self-administered questionnaire for assessing the presence and severity of ocular surface disease symptoms. The OSDI questionnaire includes 12 questions about the respondent's past week experience with the ocular symptoms, vision-related function, and environmental triggers

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Moderate to severe acne on isotretinoin

Exclusion criteria

* Occular diseases causing dry eye * Pregnant females

Design outcomes

Primary

Measure	Time frame	Description
Total ocular surface disease index (OSDI) SCORE	3 months	Total OSDI score ranged from 0 to 100 with means greater symptom severity

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026