Obesity
Conditions
Keywords
dihydrogen, appetite, LDL cholesterol, supplementation
Brief summary
The main goal of this study is to investigate how dihydrogen supplementation impacts body composition, appetite, quality of life specific to obesity, and levels of the hormone GLP-1 in men and women with obesity. This randomized controlled trial aims to explore whether dihydrogen can improve these health indicators.
Detailed description
The primary aim of this randomized controlled trial is to evaluate the effects of dihydrogen supplementation on body composition indices, appetite, obesity-specific quality of life, and circulating GLP-1 levels in obese men and women
Interventions
DIETARY_SUPPLEMENTDietary Supplement: Hydrogen-rich water
Hydrogen-rich water with 12 mg of hydrogen per serving
DIETARY_SUPPLEMENTDietary Supplement: Control water
Control water with 0 mg of hydrogen per serving
Sponsors
University of Novi Sad, Faculty of Sport and Physical Education
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-65 years * Body fat \> 30% in women and \> 25% in men * Not physically active * Informed consent signed
Exclusion criteria
* Major chronic disease and acute injuries * History of dietary supplement use during the past 4 weeks * History of obesity pharmaceuticals use during the past 8 weeks * No consent to randomization * Participation in other studies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Appetite | Change from baseline appetite at 8 weeks | Total scores for appetite as assessed by the the Food Cravings Questionnaire (FCQ) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body fat | Change from baseline body fat at 8 weeks | Percentage of body fat as assessed by a multifrequency bioelectrical impedance analyzer |
| Serum GLP-1 | Change from baseline GLP-1 at 8 weeks | Serum levels of glucagon-like peptide-1 (GLP-1) |
| Obesity-related quality or life | Change from baseline total scores for obesity-related quality of life at 8 weeks | Total scores for obesity-related quality of life as assessed by the The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire |
Countries
Serbia
Outcome results
None listed